Butronic dating

Gastrointestinal bleeding, ulceration and perforation: GI bleeding, ulceration or perforation, which can be fatal, has been reported with all NSAIDs at any time during treatment, with or without warning symptoms or a previous history of serious Gl events.Patients with a history of Gl toxicity, particularly when elderly, should report any unusual abdominal symptoms (especially GI bleeding) particularly in the initial stages of treatment.

Long-term treatment: All patients who are receiving NSAIDs should be monitored as a precautionary measure e.g.renal function, hepatic function (elevation of liver enzymes may occur) and blood counts.Pregnancy and lactation: Congenital abnormalities have been reported in association with NSAID administration in man; however, these are low in frequency and do not appear to follow any discernible pattern.Use of Aceclofenac in patients with hepatic porphyria may trigger an attack.Caution in patients with a history of hypertension and/or heart failure as fluid retention and oedema have been reported in association with NSAID therapy.

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Lithium: Aceclofenac, like many NSAIDs, may increase plasma concentrations of lithium.

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